产品简介：
Nabumetone是一种可口服的非酸类抗炎剂，为有效的、选择性的COX-2抑制剂，同时是活性代谢物 6MNA 的前体物质。
物理性状及指标：
外观：……………………白色结晶性粉末
熔点：……………………80-83℃
溶解性：…………………乙醇：25mg/ml；Water Insoluble
含量：……………………≥99%
储存条件：
常温，避光防潮密闭干燥
| 产品描述 | Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selectiveCOX-2inhibitor, and is the prodrug of the active metabolite 6MNA. |
|---|---|
| 靶点 | COX-2 |
| 体外研究 | Nabumetone is a potent and selective COX-2 inhibitor. Nabumetone (50 μmol-2 mmol) dose-dependently inhibits the proliferation of K-562 and Meg-01 cells, but shows no obvious apoptotic effect. Nabumetone potentiates the apoptotic effect of ADR in the K-562 cell line. Moreover, Nabumetone reduces Bcl-2 expression. |
| 体内研究 | Nabumetone (79 mg/kg, p.o.) inhibits paw oedema and paw exudate PGE2in rats. Nabumetone does not induce gastric damage and causes only 57% inhibition of gastric mucosal 6-keto-PGF1αproduction in rats. Nabumetone (25, 50, 100 mg/kg, i.p.) dose-dependently inhibits the increase of DDC-induced mucus secretion and stimulates stress-induced mucus secretion in rats. Nabumetone (25 mg/kg, i.p.) significantly suppresses stress-induced ulcer index in rats. |
用途及描述：
科研试剂，广泛应用于分子生物学，药理学等科研方面，严禁用于人体。本品为非甾体抗炎化合物。具有抗炎、解热和镇痛作用。其作用机理可能是通过阻断环氧合酶的活性，从而抑制了前列腺素（PG）的合成。
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4801 mL | 17.4004 mL | 34.8008 mL |
| 5 mM | 0.6960 mL | 3.4801 mL | 6.9602 mL |
| 10 mM | 0.3480 mL | 1.7400 mL | 3.4801 mL |
| 50 mM | 0.0696 mL | 0.3480 mL | 0.6960 mL |
| TESTS | SPECIFICATIONS |
|---|---|
| Appearance | White crystalline powder |
| Identification | UV |
| Solubility | 25mg/ml EtOH ,clear |
| M.P | 80-83℃ |
| Purity (HPLC) | ≥99% |
- 【注意】
- ●我司产品为非无菌包装，若用于细胞培养，请提前做预处理，除去热原细菌，否则会导致染菌。
●部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，以上数据仅供参考交流研究之用。