| Source: | E.coli |
| Description: | Recombinant Mouse Interleukin-1 Receptor Antagonist Protein is produced by our E.coli expression system and the target gene encoding Arg27-Gln178 is expressed. |
| Accession: | P25085 |
| Known As: | IL-1RN;IL-1ra;IRAP;IL1 inhibitor;Il1rn;Interleukin-1 Receptor Antagonist Protein |
| Predicted Mol Mass: | 17.5 Kda |
| Apparent Mol Mass: | 16 KDa, reducing conditions |
| Endotoxin: | < 1 EU/µg as determined by LAL test. |
| Formulation: | Lyophilized from a 0.2 μm filtered solution of 20mM Histidine-HCl, 10% Trehalose, 0.05% Tween 80, pH5.3. |
| Reconstitution: | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Shipping: | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
| Storage: | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| Background: | Interleukin-1 receptor antagonist protein (Il1rn), also known as IL-1ra, IRAP or IL1 inhibitor, is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. The mouse Il1rn gene encodes a 178 amino acids (aa) protein with a 26 aa signal peptide. Mouse Il1rn protein shares 26% and 19% identity with its homologues IL-1 beta and IL-1 alpha, respectively. Il1rn can Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling, but has no interleukin-1 like activity. Recently, an recombinant human Il1rn protein is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role. |
重组小鼠白介素1受体拮抗剂蛋白(IL-1RA)
¥1,600.00
规格: 10μg
英文名字：IL-1RA,Recombinant Mouse Interleukin-1 Receptor Antagonist Protein
质量标准：>95%,BR