Bedaquiline fumarate贝达喹啉富马酸盐
分子式:C32H31BrN2O2.C4H4O4分子量:671.58
简介:Bedaquiline fumarate 是一种二芳基喹啉抗生素,能够作用于 ATP 合成酶,常用于治疗结核杆菌感染。
物理性状及指标:
外观:……………………粉末
溶解性:…………………DMSO:100 mg/mL (148.90 mM);Ethanol:4 mg/mL (5.96 mM);Water:Insoluble
含量:……………………>98%,BR
储存条件:-20°C,避光防潮密闭干燥
生物活性(仅来自于公开文献,不保证其有效性)
描述 |
Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections. |
体外 |
Bedaquiline inhibits the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L. Among slowly growing mycobacteria (SGM), bedaquiline exhibits the highest activity againstMycobacterium aviumwith MIC50and MIC90values of 0.03 and 16 mg/L, respectively. Among rapidly growing mycobacteria (RGM),Mycobacterium abscessus subsp. abscessus (M. abscessus)andMycobacterium abscessus subsp. massiliense (M. massiliense)seem more susceptible to bedaquiline thanMycobacterium fortuitum, with MIC50and MIC90values of 0.13 and >16 mg/L, respectively, for both species. Bedaquiline also shows moderate in vitro activity against NTM species. Bedaquiline has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis. |
储液配置及储存:按表中溶解性配置;如溶解困难,可以通过快速搅拌,超声或温和加热(在45-60°C下水浴)。液体稳定性报道的很少,建议现配现用,如需储存,建议:-20℃1-3月;-80℃ 3-6月。
浓度/体积/质量 |
1 mg |
5 mg |
10 mg |
1 mM | 1.4890 mL | 7.4451 mL | 14.8903 mL |
5 mM | 0.2978 mL | 1.4890 mL | 2.9781 mL |
10 mM | 0.1489 mL | 0.7445 mL | 1.4890 mL |
50 mM | 0.0298 mL | 0.1489 mL | 0.2978 mL |
【注意】
●我司产品为非无菌包装,若用于细胞培养,请提前做预处理,除去热原细菌,否则会导致染菌。
●部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,以上数据仅供参考交流研究之用。
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