T16Ainh-A01；inhibitor of TMEM16A
简介：Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor
理化性质：
| M. Wt | 416.52 |
| Formula | C19H20N4O3S2 |
| Storage | Store at -20°C |
| Purity | >97% (HPLC) |
| CAS Number | 552309-42-9 |
溶解性：DMSO 5mg/Ml
生物活性：
Inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). Inhibits EGF-induced increases in CaCC currents; blocks proliferation of tumor cells in vitro.
T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh-A01 does not alter cytoplasmic calcium and has little effect on CFTR Cl- conductance.
储液配置：
The following data is based on the product molecular weight 416.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
|
1 mM |
2.4 mL |
12 mL |
24.01 mL |
|
5 mM |
0.48 mL |
2.4 mL |
4.8 mL |
|
10 mM |
0.24 mL |
1.2 mL |
2.4 mL |
|
50 mM |
0.05 mL |
0.24 mL |
0.48 mL |
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