Daratumumab

¥600.00¥2,000.00

CAS 号: 945721-28-8
质量标准:>95%,蛋白原液
货号: MB2803

Daratumumab;达雷木单抗

产品简介:

Daratumumab is a recombinant IgG1k monoclonal antibody that binds to CD38 and leads to cell apoptosis. Daratumumab was granted orphan drug designation for the treatment of multiple myeloma, diffuse large B cell lymphoma, follicular lymphoma, and mantle cell lymphoma.
分子式:C6466H9996N1724O2010S42分子量:145.39KD
产品形式:蛋白原液。每种装于冻存管中,单抗质量为标示数量1mg或者5mg,体积根据其浓度不同略有不同。

质量标准:
Non-reduced CE-SDS:………………………………………….>90%;
SEC-HPLC:………………………………………………………….>95%;
Bacterial Endotoxins Test:…………………………………. .<10EU/ml
Residual Proteins of Host Cell: ……………………………. <100 ng/mg
Exogenous residual DNA: …………………………………. . <100pg/mg
Residual Protein A: ……………………………………………. .<100 ng/mg
Biological Activity:………………………………………….……. .80% to 125% of standard

储存条件:

-70 ± 15℃ for long-term storage, 2-8℃ for short-term storage, away from light.

运输条件:

干冰运输

使用建议:
  • meilunbio提供的产品为蛋白原液形式。每种装于冻存管中,单抗质量为标示数量1mg或者5mg,体积根据其浓度不同略有不同。
  • 使用前可以根据自己实验需求进行稀释,溶剂建议用去离子无菌水(meilunbio货号MA0028,去离子无菌水(细胞培养用水))或者PBS(meilunbio货号MA0015,PBS(1X),细胞培养级)。
  • 不建议使用含有防腐成分的稀释液进行稀释,会增加细胞或者动物毒性。
  • 稀释前,计算加入多少体积溶剂,请参考购买批次质检单上蛋白浓度,或者询问我司;举例,质检单显示该批次单抗蛋白原液蛋白浓度为 50mg/mL;对应5MG包装的蛋白原液体积为5mg(质量)/50mg/mL(浓度)=0.1mL;实验需求蛋白浓度为10mg/mL, 需要稀释倍数为 50/10=5, 则需要加入0.4mL,即400ul PBS或者无菌去离子水即可。
  • 若给药量为固定质量值,比如单次给药0.5mg,对应蛋白原液给药体积为10ul,建议稀释后,提高给药体积降低误差,因为注射器或者移液器吸头残留会影响实验效果。
  • 稀释后的蛋白溶液,可于2-8度冷藏避光保存不超过2周,不建议长期储存。
  • 避免反复冻融,每次冻融蛋白活性会降低约5%左右。

生物活性(仅来自于公开文献,不保证其有效性)

描述 Daratumumab is a recombinant IgG1k monoclonal antibody that binds to CD38 and leads to cell apoptosis. Daratumumab was granted orphan drug designation for the treatment of multiple myeloma, diffuse large B cell lymphoma, follicular lymphoma, and mantle cell lymphoma.
靶点 CD38
Application antitumor agent

用途及描述:

仅供科研,严禁用于人体(For R&D Only)

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规格

1mg, 5mg

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