盐酸氯丙嗪
分子式：C17H19ClN2S.HCl分子量：355.32
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产品描述 |
Chlorpromazine是一种多巴胺和钾离子通道抑制剂，IC50分别为6.1和16 μM。 |
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靶点 |
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IC50 |
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生物活性 |
Chlorpromazine (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 µM for nward-rectifying K+ currents and time-independent outward currents.In inhibits prolactin release inhibitory factor, thus stimulating the release of prolactin. The turnover of dopamine in the brain is also increased. Chlorpromazine blocks a variety of K+ channels in heart muscle cells. Inasmuch as the potency of inhibition is less than the previously reported use-dependent block of Na+ channels, the cardiovascular adverse effects of chlorpromazine are probably caused mainly by the latter effect. |
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溶解性 |
DMSO 71 mg/mL，水71 mg/mL，乙醇71 mg/mL |
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稳定性 |
2年-20°C粉状，6月-80°C溶于DMSO |
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特征 |
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运输条件：常温运输
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