重组小鼠LR3胰岛素样生长因子LR3-IGF-I

¥260.00

规格: 10μg

英文名字:LR3 Insulin-Like Growth Factor-I,Mouse,Recombinant(C-6His)
质量标准:>95%,BR
货号: MA1317-1
Source: E.coli
Description: Recombinant Mouse Insulin-like Growth Factor I is produced by our E.coli expression system and the target gene encoding Gly49-Ala118 is expressed with a 6His tag at the C-terminus.
Accession: P05017
Known As: IGF1; IGF-1; insulin-like growth factor 1; Insulin-like growth factor I;Somatomedin C; somatomedin-C
Predicted Mol Mass: 10.2 Kda
Apparent Mol Mass: 12 KDa, reducing conditions
Endotoxin: < 1 EU/µg as determined by LAL test.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM NaAc, pH 4.5.
Reconstitution: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping: The product is shipped at ambient temperature.
Upon receipt, store it immediately at the temperature listed below.
Storage: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Background: Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides. These isoforms are differentially expressed by various tissues. Mature mouse IGF-I shares 94% and 99% aa sequence identity with human and rat IGF-I, respectively, and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II.  IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally. It plays an important role in muscle regeneration and tumor progression. IGF-I binds IGF-I R, IGF-II R, and the insulin receptor. IGF-I association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors.

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