二氢细胞松弛素;Dihydrocytochalasin B
分子式:C29H39NO5 分子量:481.62
物理性状及指标:
外观:……………………白色结晶
熔点:……………………203~205°C
溶解性:…………………溶于有机溶剂如乙醇(20mg/ml)DMSO(20mg/ml)
炽灼残留:………………<0.1%
纯度:……………………>98%
重金属:…………………<0.002%
生物活性
Dihydrocytochalasin B (DCB) is a member of the cytochalasin mycotoxin family that inhibits actin assembly. It blocks cleavage furrow formation and cytokinesis in synchronous HeLa cells at a concentration of 10 μM. DCB induces tetraploidy and arrests the cell cycle indefinitely in the G1 phase in REF-52 cells. It also increases the drug sensitivity of multidrug resistant SKVLB1 cells to paclitaxel (Item No. MB1178) and doxorubicin (Item No.MB1087)in vitro.
用途及描述:
科研试剂.用于膜蛋白的溶解,透化细胞和细胞核膜
储存条件:
-15~-20°C