简介：亚叶酸Folinic acid是肿瘤化疗药methotrexate等的佐剂。
别名：leucovorin
物理性状及指标：
外观：………………solid
溶解性：……………Sparingly soluble in water
含量：………………>98%
储存条件：-20℃，避光防潮密闭干燥
运输条件：2~8℃运输
生物活性
Folinic acid is an adjuvant used in cancer chemotherapy involving the drug methotrexate. Target: Antifolate Folinic acid is a 5-formyl derivative of tetrahydrofolic acid. It is readily converted to other reduced folic acid derivatives (e.g., tetrahydrofolate), and, thus, has vitamin activity that is equivalent to that of folic acid. Since it does not require the action of dihydrofolate reductase for its conversion, its function as a vitamin is unaffected by inhibition of this enzyme by drugs such as methotrexate. In 1980s, however, folinic acid was found to reactivate the dihydrofolate reductase itself even when methotrexate exists. Although the mechanism is not very clear, the polyglutamylation of methotrexate and dihydrofolate in malignant cells is considered to play an important role in the selective reactivation of dihydrofolate reductase by folinic acid in normal cells . Folinic acid is generally administered along with MTX as a rescue agent to decrease MTX-induced toxicity. However, information regarding the inhibitory effect of folinic acid against cytogenetic damage caused by MTX is limited. This study was conducted to assess the cytogenetic effect of MTX and its inhibition by folinic acid (FA) using the micronucleus and chromosomal aberration assays concurrently .
用途及描述：科研试剂，广泛应用于分子生物学，药理学等科研方面，严禁用于人体。
【注意】
●我司产品为非无菌包装，若用于细胞培养，请提前做预处理，除去热原细菌，否则会导致染菌。
●部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，以上数据仅供参考交流研究之用。亚叶酸的溶解性，亚叶酸在水中的溶解性，亚叶酸在生理盐水中的溶解性，亚叶酸在PBS缓冲液中的溶解性，亚叶酸在DMSO、乙醇等有机溶剂中的溶解性，亚叶酸在细胞实验方面的应用，亚叶酸在大鼠等动物实验方面的应用。以上相关信息请直接联系大连美仑生物技术公司，我司将随货提供部分的参考信息。（注意，部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用）
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