Dibutyryl-cAMP (Bucladesine)是一种细胞可渗透性 PKA 激活剂,通过模拟内源性 cAMP 发挥作用。
理化数据
分子量 |
491.37 |
化学式 |
C18H23N5NaO8P |
CAS号 |
16980-89-5 |
稳定性 |
3 years -20°C powder |
溶解性
H2O: soluble50mg/mL
生物活性
细胞通透性 cAMP 类似物,可激活 cAMP 依赖性蛋白激酶 (PKA)。在 pH 8.5 下会失去 2′-O-丁酰基。
Dibutyryl cAMP is a cell-permeable cAMP analogue that activates cAMP dependent protein kinase (PKA) or the cAMP/PKA signaling pathway. Dibutyryl cAMP is used as a morphological differentiation inducer and cell signaling modulator in cells such as Schwann cells. It is used in a variety of neural differentiation studies.
储存条件:Store at -20° C
运输条件:2~8℃运输
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