Z-IETD-FMK

¥1,280.00¥3,980.00

CAS 号: 210344-98-2
英文名字:Z-IETD-FMK
质量标准:>98%,Caspase-8抑制剂
货号: MB4577

Z-IETD-FMK是一种特异性Caspase-8抑制剂。

理化数据

分子量

654.68

化学式

C30H43FN4O11

CAS号

210344-98-2

稳定性

3 years -20°C powder

2 years -80°C in solvent

溶解性

DMSO

91 mg/mL (138.99 mM)

Water

<1 mg/mL 难溶或者不溶

Ethanol

<1 mg/mL 难溶或者不溶

生物活性

产品描述 Z-IETD-FMK是一种特异性Caspase-8抑制剂。
靶点
Caspase-8
体外研究 Z-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli. Z-IETD-FMK (50 μM) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production, and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures.
体内研究 In vivo, inhibition of caspase-8 by Z-IETD-FMK reduces memory/activated CD4 and CD8 T cells, and increases susceptibility to T. cruzi infection. Z-IETD-FMK promotes neuronal survival and regeneration of injured retinal ganglion cells after CNS injuries
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规格

1mg, 5mg

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