Indirubin-3′-oxime；靛玉红-3′ -单肟
Alternate Names:Indirubin-3′-monoxime
Chemical Name:3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
M.Wt: 277.28
Formula: C16H11N3O2
Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:>98%
Biological Activity
Protein kinase inhibitor; inhibits cyclin-dependent kinases (IC50 = 0.18 – 3.33 μM) and GSK-3β (IC50 = 0.19 μM). Inhibits CDK5- and GSK-3β-mediated tau phosphorylation, a process over-active in Alzheimer disease states. Also inhibits AMPK, LCK and SGK. Induces cell cycle arrest and inhibits cell proliferation
Storage: 2~8℃
Transportation conditions: normal temperature transportation
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